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BACKGROUND:
30+ years as a highly productive professional chemist including:
- Developed new analytical test methodology to solve practical problems
- Applied chromatographic techniques to solve industrial problems
- Managed the development of over 200 analytical methods
- Support to Generic Drug programs - material science and analytical
chemistry
- Developed new elastomeric compounds for pharmaceutical applications
- Converted medical products from latex to synthetic polyisoprene
compounds
- Managed analytical method development laboratories
- Provided analytical consulting
ACCOMPLISHMENTS:
*Awarded a SBIR grant by the US Army for the development of a non-microscopic method of analysis to detect malaria in blood
* Awarded a Fulbright Senior Research Scholarship to conduct research
at the National Academy of Science Ukraine at the Institute of Single
Crystals on microwave-assisted chemical synthesis of acetylated
iminocoumarines using HPLC and NMR
- Awarded trade secrets for an improved probe for FORS measurement of
viscous materials and a gas permeation analyzer for measuring permanent
gas permeation through polymer films
Managed the development of rubber injection-compression molding
technology for the production of pharmaceutical elastomer closures and
IV set components
- Recommended process analytical solution to environmental wastewater
problem and assisted in installing analyzer to measure vinyl chloride
in wastewater using process GC
- Coordinated the conversion of several pharmaceutical and consumer
products from rubber compounds containing natural rubber to a synthetic
polyisoprene equivalent material
- Develop a diode array/fiber optic based clear acrylic multicuvette
analyzer as a QA tester for production of the cuvettes to insure
optical clarity and equivalency of the product
- Initiated process analytical process program including Center for
Process Analytical Chemistry sponsorship, purchase of 5 process
analyzers i.e. NIR and fiber optic remote spectroscopy (FORS)
- Demonstrated the application of FORS – fiber optic remote
spectroscopy- (grating and diode array technology) for monitoring
polymerization catalyst levels, determining %polymer solids
in
polymer cement, measuring acrylonitrile in an aqueous recycle stream,
monitoring molten (250ºC) PET, and tracking uniformity of
rubber
mixing in an extruder
- Developed NIR reflectance and transmission methods for measuring
polymer functional groups, polymer additives, polymer microstructure,
silicone in resin, oil in rubber, powdered chemical mixture
compositions, and ppm levels of an organic solvent in wastewater
Education
- PhD, Analytical Chemistry, Case Western Reserve,
Cleveland, OH 1976
- BA, Chemistry, Houghton College, Houghton,
NY 1968
- Attended several Gordon Research Conferences in the 1980s –
Analytical Chemistry & Separation Science as well as Pittsburgh
Conference.
- Attended Polymer Morphology course coordinated by RPI in
New Orleans 1993
- Attended Gordon Research Conference on Elastomers
New London NH 1995, 1999
- Attended Analysis of Polymers, University of Twente, Enschede,
Netherlands, 2002
- Attended Heal Ohio, Wound Healing Consortium, Akron, OH October 2008
Current
Employment
2008:
- President and Founder Manning Wood, LLC, Uniontown, OH
- consulting clients include contract analytical labs and several healthcare/ pharmaceutical companies
-
part-time Sr. Lecturer at the University of Akron, Department of
Chemistry, teaching General, Organic, and Biochemistry to pre-nursing
students
- part-time Adjunct Prof at Kent State University - Stark, Department of Chemistry, teaching General Chemistry
- Professional Activities
- American Chemical Society member
- Parenteral Drug Association member
Employment
Fulbright Senior Research Scholar: Jan- Jun 2007
-coauthored
a book with two colleagues from the Institute of Single Crystals in
Kharkiv, Ukraine. Aza-heterocycles based on alpha, beta-Unsaturated Carbonyls
(Springer Verlag) published October 2008
HPLC and NMR Analysis of Heterocyclic Amines, Institute of
Single Crystals, Kharkiv, Ukraine
Abbott Laboratories until May 2004 then Hospira Inc.
Technical Director 1996-2006
Direct two groups (15 people) - Polymer Science and Product
Development. Provide overall direction for the research and
development activities at the plant. Responsible for
developing
new polymeric materials, products, processes, and supporting existing
manufacturing processes.
Manager Rubber Technology 1993-1995
Managed 9 chemists and technicians including the analytical
lab.
Responsible for development of new rubber products mainly
elastomeric closures, stoppers, reseals, baby bottle nipples, sponge,
golf ball centers, and hot water bottles. The R&D
group
supported all production of current products.
Managed the implementation of several conversion programs from natural
rubber based compounds to all synthetic polyisoprene compounds for baby
bottle nipples and IV elastomeric components. Presented
seminar
on isoprene polymers synthetic vs. natural. Managed the
implementation of rubber injection molding technology for production of
pharmaceutical stoppers, syringe plungers, and IV components - sleeves,
flashbacks and septa. Coordinated drug closure programs for
several generic drug programs at Corporate R&D.
Developed
program to extrude and cure polyisoprene compound into tubing for use
in irrigation surgical sets.
Upgraded the analytical lab with the purchase of a HPLC (DAD) with
heart-cutting capabilities into a GC/MSD for characterization
of
rubber stopper impurities. Solved analytical problems working
cooperatively with Corporate R&D. Managed the
development of
a streamlined GC-TEA method for the determination of nitrosamines in
baby bottle nipples. Presented seminars at Corp R&D
to
analytical chemists and pharmacists on Pharmaceutical Rubber Chemistry
and a workshop on Analytical Chemistry of Rubber at Corporate
R&D.
Sr. Analytical Chemist 1992- 1993
Managed 2 technicians. Responsible for analytical support for
production of rubber and plastic medical and consumer
products.
Major analytical techniques utilized were chromatography, IR, XRF, AA,
and microscopy. Coordinated program to evaluate new
thermoplastic
elastomeric materials (TPEs) for pharmaceutical applications.
Developed new analytical testing instrumentation using fiber optics
technology for an acrylic clear multicuvette for blood testing.
ICI Americas, Specialty Chemicals Group Leader, Separation Science
1991-1992
Managed 2 professionals and 6 technicians. Responsible for
analytical support to the various businesses within the Corporation.
Goodyear Tire & Rubber Co 1976-1991
Senior Research Chemist, Methods
Development (1976-1982)
Developed over 30 new analytical methods for organic chemicals and
polymers used in the rubber and chemical industry, trace analysis, air
pollutants, wastewater, and FDA required analyses of extractables in
polyester beverage containers.
Section Head, Methods
Development (1982-1991)
Managed 7-15 professionals- PhDs and technicians. Responsible
for
developing analytical methods using GC, HPLC, GC/MS, GPC, IC, NMR, IR,
NIR, UV, AA, pyrolysis MS, fiber optic UV/NIR, flow injection analysis
(FIA), and wet chemistry. These methods were designed for
both
R&D project support and implementation in plant analytical
laboratories for QA analyses.
Major responsibilities as section head included coordinate and direct
method development effort; consult/advise technical personnel on
analysis problems; keep abreast of current literature to maintain
application of state-of-the-art technology; evaluate and recommend
purchase of analytical instrumentation, maintain inventory file of
in-house analytical methods; perform administrative tasks related to
personnel.
Initiated company sponsorship of the Center for Process Analytical
Chemistry (CPAC) at the University of Washington, Seattle.
Represented the company on the CPAC advisory board. Developed
programs and expertise in process analytical techniques - fiber optic
remote spectroscopy, near infrared reflectance, chemometrics, FIA,
process GC, and pulsed NMR.
MILITARY
US Army Security Agency, German Linguist
(West Berlin) 1968-1972
Publications
Books
Aza-heterocycles based on alpha, beta-Unsaturated Carbonyls
(Springer Verlag) V Chebanov, S DeSenko, and T Gurley, published October 2008
Journal articles
- Oxygen Permeation and Microbial Ingress through a film coated and
uncoated elastomeric closure in a glass drug vial.
M
Andress, H Dull, T Gurley, T Berger, E Remo, and J Grillo.
Journal of the Parenteral Drug Association, 2004, vol 58 (1), pp. 32-44
- Rapid Analytical Method for the Determination of Nitrosamines in Baby
Bottle Nipples, M Andress, T Gurley, and S Harsch, Rubber &
Plastics News - Technical Notebook July 1998.
- Determination of Microstructure and Composition in Butadiene and
Styrene-Butadiene Polymers by Near-Infrared Spectroscopy, C Miller, B
Eichinger, T Gurley, J Hermiller, Analytical Chemistry, 1990, 62,
1778-1785.
- Determination of Terephthalic Acid at the Low Parts-per-Billion Level
by Reverse Phase HPLC, T Gurley, Journal of Chromatographic Science,
1980, 18, 39-41.
- Analysis of Organophosphorus Compounds at the Parts-per-Million Level
by Phosphorus-31 Fourier Transform NMR Spectroscopy, T Gurley and W
Ritchey, Analytical Chemistry, 1976, 48, 8, 1137-1140.
- Phosphorus-31 Fourier Transform Nuclear Magnetic Resonance
Spectrometry as a Trace Analysis Tool for the Determination of
Inorganic Phosphates, T Gurley and W Ritchey, Analytical
Chemistry, 1975, 47, 8, 1444-1446
- Ph.D. Thesis Phosphorus-31 Fourier Transform NMR
Spectroscopy as a tool for trace analysis of Phosphorus
Compounds. Thesis Advisor: William Ritchey, Case
Western
Reserve University, June 1976
Presentations
- Pharmaceutical Elastomer University
- Application and Limitations of TPEs for Use in Pharmaceutical
Products, New Biomedical Developments in TPES, ACS
Rubber
Division meeting, Akron, Ohio, May 2006
- Shedding the Coating Myth: A Comparison Coated and Uncoated Drug
Closures, PDA Extractables Conference,
poster, May
2005
-Synthetic
Polymers used in Pharmaceutical Applications, Wound Healing
Consortium, Akron General Hospital, Akron, OH, March 2008
-Polymers that can save your Life, 2008 American Institute of Chemical
Engineers Regional meeting, University of Akron, Akron, OH March 2008
Consulting Services
Extractables and leachables in:
·
pharmaceutical rubber
·
synthetic and natural rubber
· flexible
PVC and other polymers
· plastic
materials
Applications of analytical chemistry
· problem
solving
·
characterization
· methods
development – chromatography / spectroscopy
·
quantitative analyses
· process
analytical chemistry methods
Training
Services
- Training on pharmaceutical rubber formulations – chemistry,
rheology, drug interactions, generic drug strategies (Pharmaceutical Elastomer University
- Training on USP, EP, JP requirements 87, 88, 381, 661
- Strategic business planning SWOT analyses
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